This inherited red blood cell disorder is the most common genetic disease in America, and one of the most painful and debilitating. Until now, bone marrow and cord blood transplants have been the only treatment available to patients, and matched donors are hard to find. But an experiment at Genetix in Cambridge, Massachusetts is raising hopes. By treating the bone marrow of mice with anti-sickling gene therapy, scientists saw great improvement in normal red blood production.All 50 Secrets of the Sequence videos have an accompanying classroom-tested lesson that encourages students to further explore the video topics. Each lesson includes background information, state and national science standards, discussion questions and answers, teacher notes and an activity that will ensure a hands-on, minds-on experience. To see lessons for this series, visit http://www.pubinfo.vcu.edu/secretsoft….

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